Blood Biomarker Discovery
The discovery of blood-circulating biomarkers is hindered by the large dynamic range of blood components and the low concentration of disease-specific molecules. We employ the Nanoomics platform in order to facilitate the discovery of novel biomarker panels in blood (using both preclinical models and human clinical samples), for a range of diseases and biomarker applications with an emphasis on the early detection of cancer and neurodegenerative diseases. We aim to develop nanoparticle-based ‘liquid biopsy’ platforms to harvest disease-specific molecules across multiple omics ‘layers’.
Relevant Publications
Cell Reports Medicine
Combined multi-omics and multi-spectral profiling of plasma extracellular vesicles reveals liquid biopsy biomarkers for glioma diagnosis
Stephen David Robinson, Biniam Tsegay Haile, Matthew Reily-Bell, Olivia Iwanowytsch, Siobhan Palmer, Dorte Schou Nørøxe, Panagiota S. Filippou, Joanna Renaut, Alan Lazarus, Georgios Antoniou, Mark Samuels, Viviana Vella, Chrysa Filippopoulou, William Jones, Josephine Jung, Xiaoou Li, Nan Ji, Yang Zhang, Aleena Azam, Jane Skjoeth-Rasmussen, Ulrik Lassen, Adriana Saraiva, Ahmad Taha, Tania Slatter, Greg Jones, Rajesh Katare, Holly J. Butler, Matthew J. Baker, Marilena Hadjidemetriou, Duncan Gilbert, Benjamin Towler, Keyoumars Ashkan, Giles Critchley, Frances M.G. Pearl, and Georgios Giamas.
Nature Communications
Plasma-to-tumour tissue integrated proteomics using nano-omics for biomarker discovery in glioblastoma
Xinming Liu, Hanan Abmanhal-Masarweh, Olivia Iwanowytsch, Emmanuel Okwelogu, Kiana Arashvand, Konstantina Karabatsou, Pietro I D'Urso, Federico Roncaroli, Kostas Kostarelos, Thomas Kisby*, Marilena Hadjidemetriou*
Communications Medicine
Longitudinal plasma nano-proteomics reveals acute systemic responses to radiotherapy and predictive biomarkers of late toxicity
Hanan Abumanhal-Masarweh, Salam A. Assi, Xinming Liu, Conrado Guerrero Quiles, Taha Lodhi, Kaye J. Williams, Eleanor J. Cheadle, Kostas Kostarelos, Ananya Choudhury, David C. Wedge, Catharine M. L. West & Marilena Hadjidemetriou
Nature Nanotechnology
First-in-human controlled inhalation of thin graphene oxide nanosheets to study acute cardiorespiratory responses
Jack Andrews^, Shruti Joshi^, Evangelos Tzolos, Maaz Syed, Hayley Cuthbert, Livia Crica, Neus Lozano, Emmanuel Okwelogu, Jennifer Raftis, Lorraine Bruce, Craig Poland, Rodger Duffin, Paul Fokkens, John Boere, Daan Leseman, Ian Megson, Phil D. Whitfield, Kerstin Ziegler, Seshu Tammireddy, Marilena Hadjidemetriou, Cyrill Bussy, Flemming Cassee, David Newby, Kostas Kostarelos*, Mark Miller*