Blood Biomarker Discovery
The discovery of blood-circulating biomarkers is hindered by the large dynamic range of blood components and the low concentration of disease-specific molecules. We employ the Nanoomics platform in order to facilitate the discovery of novel biomarker panels in blood (using both preclinical models and human clinical samples), for a range of diseases and biomarker applications with an emphasis on the early detection of cancer and neurodegenerative diseases. We aim to develop nanoparticle-based ‘liquid biopsy’ platforms to harvest disease-specific molecules across multiple omics ‘layers’.
Relevant Publications
Nature Communications
Plasma-to-tumour tissue integrated proteomics using nano-omics for biomarker discovery in glioblastoma
Xinming Liu, Hanan Abmanhal-Masarweh, Olivia Iwanowytsch, Emmanuel Okwelogu, Kiana Arashvand, Konstantina Karabatsou, Pietro I D'Urso, Federico Roncaroli, Kostas Kostarelos, Thomas Kisby*, Marilena Hadjidemetriou*
Nature Nanotechnology
First-in-human controlled inhalation of thin graphene oxide nanosheets to study acute cardiorespiratory responses
Jack Andrews^, Shruti Joshi^, Evangelos Tzolos, Maaz Syed, Hayley Cuthbert, Livia Crica, Neus Lozano, Emmanuel Okwelogu, Jennifer Raftis, Lorraine Bruce, Craig Poland, Rodger Duffin, Paul Fokkens, John Boere, Daan Leseman, Ian Megson, Phil D. Whitfield, Kerstin Ziegler, Seshu Tammireddy, Marilena Hadjidemetriou, Cyrill Bussy, Flemming Cassee, David Newby, Kostas Kostarelos*, Mark Miller*
